Table 2. Pharmacokinetic parameters of 19 after intravenous (IV) and oral (PO) administration.

Parametera	19
IV dose (mg/kg)	1
T1/2 (h)	9.69 ± 3.15
AUC0–∞ (μg/L*h)	23318.81 ± 4501.24
Cl (L/h/kg)	0.04 ± 0.01
Vdss (L/kg)	0.35 ± 0.02
PO dose (mg/kg)	10
T1/2 (h)	8.20 ± 1.72
AUC0–∞ (μg/L*h)	53047.73 ± 11030.40
Cmax (μg/L)	5310.50 ± 1910.47
Tmax (h)	1.00 ± 0.87
F (%)	22.75 ± 4.73

^aCompound was dosed to equal number of male Sprague-Dawley rats in IV and PO administration respectively (n = 3).