Skip to main content
. Author manuscript; available in PMC: 2015 Oct 7.
Published in final edited form as: Nat Struct Mol Biol. 2007 Feb 18;14(3):185–193. doi: 10.1038/nsmb1209

Figure 8.

Figure 8

A model for transformation by SF2/ASF. SF2/ASF (which can be blocked by specific shRNAs) activates several key targets that contribute to the transformed phenotype: induction of MNK2b promotes phosphorylation of eIF4E, which enhances cap-dependent translation; induction of the oncogenic S6K1 isoform-2 directly leads to transformation; and induction of inactive isoforms of the putative tumor suppressor BIN1 inhibits apoptosis. Other SF2/ASF targets are also likely to contribute to transformation.

HHS Vulnerability Disclosure