Table 5.
Comparison of pharmacokinetic parameters obtained after oral administration of three different formulations of AZA in rabbits with an equivalent dose of 50 mg/Kg.
| Pharmacokinetic |
MKT tablet of AZA |
EC tablet of AZA | MCDDS |
|---|---|---|---|
| parameters | |||
| AUC0–∞ | 2130.76 | 2678.13 | 3380.41 |
| C max (ng/mL) | 1430.08 | 847.5 | 453.56 |
| T max (h) | 1.50 | 5.00 | 9.00 |
| Ke (h−1) | 1.024 | 0.0911 | 0.0501 |
| (t 1/2)e (h) | 0.6820 | 7.59 | 12.95 |
| AUMC0–∞ (h2·ng/mL) | 7670.73 | 17729.22 | 46677.81 |
| MRT (h) | 3.60 | 6.62 | 13.81 |
| Ka (h−1) | 3.18 | 5.6 | 11.8 |
| (t 1/2)a (h) | 0.2179 | 0.1239 | 0.0587 |
| V d (L) | 2.26 | 7.80 | 12.71 |
| TCR (L/h/kg) | 2.31 | 0.7105 | 0.6367 |