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. 2015 Jul 27;2(4):ENEURO.0049-15.2015. doi: 10.1523/ENEURO.0049-15.2015

Figure 2.

Figure 2

The HFS-induced long-term potentiation of the PSP in CA2 is dependent on GABAergic transmission. A, Time course of average normalized fPSP amplitude recorded in CA1 SR in response to SC stimulation, showing that the HFS-induced increase in PSP amplitude in control conditions (open circles, p = 0.0020, n = 5) was facilitated in the continuous presence of the GABAA and GABAB receptor antagonists 1 μm SR 95531 and 2 μm CGP 55845 (filled circles, p = 0.0017, n = 8). B, C, In CA2, HFS does not trigger long-lasting increase in the SC PSP amplitude in the continuous presence of GABA receptor antagonists (filled circles; B, extracellular recordings, p = 0.09, n = 10; C, whole-cell recording, p = 0.6997, n = 10), but evokes a large and lasting increase in the PSP amplitude in control experiments (open circles; B, extracellular recordings, p < 0.00001, n = 10; C, whole-cell recording, p < 0.00001, n = 10). In all panels, averaged PSP traces corresponding to the time points before (a) and after (b) HFS are shown on the right. Error bars indicate the SEM in all panels.