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. 2015 Oct 7;9:384. doi: 10.3389/fncel.2015.00384

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Copyright © 2015 Gao, Song, Zhu, Wang, Hao, Nadler and Zhan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Representative traces comparing spontaneous and evoked firings in mature granule cells of the control and SE groups. The CAG-GFP retroviral vector was injected into the dentate gyrus 5 days after pilocarpine-induced SE or saline injection. Brain slices were prepared at least 10 weeks after retroviral vector injections. (A) Fluorescent (GFP) and differential interference contrast (DIC) images show recorded cells from a control (Control) and a rat suffering from SE before retroviral vector injection. (B) Spontaneous firing recorded in cell-attached mode. Note that no spontaneous firings were noticeable. (C) Evoked firing recorded in whole-cell mode. The current injection traces are shown beneath the membrane potential traces. Note that a doublet of bursting is seen in response to 70 pA current injection in the SE rat.