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ERK5 icKO mice performed similarly to the controls in the elevated-plus maze. Mice were placed in the elevated-plus maze and allowed to explore for 5 min. Exploratory activity and immobility were analyzed by AnyMaze Software. A, Time spent in open arms and closed arms. B, Time spent in open and closed ends (the distal one-third of the open and closed arms). C, Time spent immobile in the open and closed arms. D, Total time immobile in the entire maze. n.s., Not significant.
