Figure 8.

Administration of MK-801, prior to a shift to a VR5 schedule of reinforcement, significantly impaired the reconsolidation of long-term lever pressing for cocaine self-administration in a reactivation-dependent manner. A, Lever pressing at test was significantly reduced in rats administered MK-801 prior to the VR5 reactivation (n = 7) compared with both reactivated vehicle-injected rats (n = 7) and the non-reactivated MK-801-treated group (n = 6). Non-reactivated vehicle rats (n = 6) showed similar performance to their reactivated counterparts. B, Treatment with MK-801 had no significant effect on nosepoking behavior regardless of when animals received memory reactivation. Data are represented as mean + SEM.