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. 2015 Apr 24;2(2):ENEURO.0053-14.2015. doi: 10.1523/ENEURO.0053-14.2015

Figure 4.

Figure 4

Dimerization between MC3R and GHSR1a results in amplification of MC3R signaling and attenuation of GHSR1a signaling. While it is believed that the pathways involved are not changed, changes in the amplitude of the signals occur. Dimerization with stimulation of MC3R leads to a twofold amplification of MC3R-induced cAMP accumulation (top), while the GHSR1a protomer shows a ligand-dependent as well as ligand-independent 40% reduction in Ca2+ accumulation when dimerized with MC3R (bottom). Amplification of MC3R signaling appears to be dependent on GHSR1a’s constitutive activity.