Figure 7.

Dual-color super-resolution microscopy of Arc-mEOS2 and endogenous Tip60. A representative z-plane of a hippocampal neuronal nucleus after 4 h of network activation by 4AP-bicuculline-forskolin treatment (see Materials and Methods), showing the single-molecule distribution Arc-mEOS2 (green) imaged using 3D PALM and endogenous Tip60 (red) imaged using dSTORM. Cyan-colored squares outline distinct areas of association between Arc and Tip60 proteins, which were consistently found across reconstructed z-sections. Scale bar, 2 μm. The bottom panel shows detailed images at higher magnification. Scale bar, 200 nm.