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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Expert Rev Clin Immunol. 2014 Oct 18;10(12):1703–1709. doi: 10.1586/1744666X.2014.971014

Table 2.

Isoforms of IL-37, their expression and biological role [2].

Isoform Expression Biological Role
IL-37a Brain, lymph nodes, thymus, bone marrow, lung, testis, placenta, uterus, skin, colon, NK, monocytes, stimulated B cells, keratinocytes May be functional
IL-37b Heart, lymph nodes, thymus, bone marrow, lung, testis, placenta, uterus, skin, colon, NK, monocytes, stimulated B cells, keratinocytes Biologically functional isoform with the greatest amount of exons.
IL-37c Kidney, lymph nodes, thymus, bone marrow, lung, testis, placenta, uterus, skin, colon, NK, monocytes, stimulated B cells, keratinocytes Non-functional, due to abnormal folding
IL-37d Testis and bone marrow May be functional
IL-37e Testis and bone marrow Non-functional, due to abnormal folding