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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Expert Rev Clin Immunol. 2014 Oct 28;10(12):1711–1730. doi: 10.1586/1744666X.2014.975692

Figure 3. Th17 cell subsets offer distinct roles in tumor progression.

Figure 3

Th17 cells induced by TGF-β and IL-21 generally elicit a pro-tumor effect, whereas those induced by IL-6 and IL-23 are anti-tumorigenic due to the recruitment of cytotoxic lymphocytes (CTL) and the promotion of innate immune cells.. Levels of IL-17 and IFNγ are implicated in these opposing Th17 activities.