Table 3.

Cox Regression Analyses of Variables Associated with Survival after Liver-Directed Procedures for Patients with Fibrolamellar Carcinoma or Hepatocellular Carcinoma from 1998 to 2008

Prognostic factor	Univariate			Multivariate
Prognostic factor	Hazard ratio	95% CI	p Value	Hazard ratio	95% CI	p Value
Age > 58y	1.51	1.42–1.62	<0.001	1.41	1.32–1.51	<0.001^*

Female sex	1.024	0.95–1.10	0.516	–	–	–

Year of diagnosis quartile

1986–2001	–	Reference		–	–	–

2002–2004	1.62	1.42–1.86	<0.001	1.74	1.52–1.99	<0.001^*

2005–2006	1.35	1.18–1.55	<0.001	1.35	1.18–1.55	<0.001^*

2007–2008	1.20	1.04–1.39	<0.001	1.15	1.01–1.33	0.049^*

Race

White	–	Reference		–	–	–

Asian/Pacific Islander	1.62	1.16–2.26	0.005	1.44	1.03–2.02	0.032^*

Black	1.52	1.09–2.14	0.014	1.23	0.88–1.74	0.217

Other	2.05	1.45–2.90	<0.001	1.86	1.31–2.63	<0.001^*

Regional disease	1.62	1.51–1.75	<0.001	1.55	1.44–1.66	<0.001^*

Grade

Well-differentiated	–	Reference		–	–	–

Moderately differentiated	1.20	1.09–1.32	<0.001	0.74	0.70–0.82	<0.001^*

Poorly differentiated	1.77	1.77–1.58	<0.001	0.96	0.89–1.05	0.399

Undifferentiated	1.67	1.28–2.18	<0.001	1.40	1.25–1.56	<0.001^*

Unknown	1.44	1.32–1.58	<0.001	1.26	0.96–1.63	0.089

Liver-directed procedure

Resection or hepatic transplant	–	Reference		–	–	–

Ablation only	1.52	1.67–1.92	<0.001	1.79	1.66–1.93	<0.001^*

Surgery, not otherwise specified	1.79	1.23–1.86	<0.001	1.39	1.13–1.71	0.002^*

Hepatocellular carcinoma	1.69	1.23–2.32	0.001	1.65	1.20–2.28	0.002^*

Significant.