Table 1.
Properties of unloaded and OVA-loaded NPs. SD were calculated on three different batches
| Code | OVA % w/w | Mean DH nm ± SD | P.I. | Zeta potential mV ± SD | PEI loading mg/100 mg NPs | OVA actual loading mg/100 mg NPs (Entrapment efficiency %)a |
|---|---|---|---|---|---|---|
| PLGA NPs | - | 175 ± 12 | 0.165 | −32.8 ± 5.6 | - | - |
| OVA-PLGA NPs | 4 | 253 ± 16 | 0.166 | −32.1 ± 2.0 | - | 3.6 ± 0.7 (92.9 ± 17.4) |
| PLGA/PEI NPs | - | 172 ± 5 | 0.162 | +36.3 ± 4.0 | 6.2 | - |
| OVA-PLGA/PEI NPs | 4 | 161 ± 9 | 0.147 | +42.9 ± 5.3 | 6.6 | 3.3 ± 0.4 (77.5 ± 10.3) |
aRatio between actual and theoretical loading x 100