Table 3.
Correlation between tDMCs and the level of gene expression from the neocortex, muscle and spleen
| Tissue type | Gene | Chra | Position | Classb |
Mc | Ed | Pearson's corr.e | |
|---|---|---|---|---|---|---|---|---|
| Neocortex | NRXN2 | 2 | 6587361 | UP10K | − | + | −0.897000684 | |
| 2 | 6635041 | Genebody | − | + | −0.838015353 | |||
| 2 | 6635090 | Genebody | − | + | −0.886097969 | |||
| 2 | 6635002 | Genebody | − | + | −0.828919384 | |||
| 2 | 6634986 | Genebody | − | + | −0.902681422 | |||
| 2 | 6634955 | Genebody | − | + | −0.802729923 | |||
| 2 | 6634980 | Genebody | − | + | −0.874609127 | |||
| 2 | 6634930 | Genebody | − | + | −0.720944026 | |||
| 2 | 6634961 | Genebody | − | + | −0.837225041 | |||
| 2 | 6634934 | Genebody | − | + | −0.785419851 | |||
| 2 | 6634951 | Genebody | − | + | −0.865604511 | |||
| MAPT | 12 | 17133831 | Genebody | − | + | −0.926451406 | ||
| 12 | 17133834 | Genebody | − | + | −0.922834214 | |||
| SYNE1 | 1 | 16124463 | Genebody | − | + | −0.80723621 | ||
| 1 | 16124489 | Genebody | − | + | −0.750224969 | |||
| Muscle | CCDC88C | 7 | 119491407 | Genebody | + | − | −0.936174813 | |
| EXOC2 | 7 | 75292 | Genebody | CGI shore | + | − | −0.851066176 | |
| 7 | 75340 | Genebody | CGI shore | + | − | −0.832158353 | ||
| FGR | 6 | 78329214 | Genebody | CGI shore | + | − | −0.802870198 | |
| 6 | 78336406 | Genebody | + | − | −0.755515526 | |||
| MAP2K7 | 2 | 71712421 | UP10K | + | − | −0.857718538 | ||
| NR5A2 | 10 | 27361479 | Genebody | − | + | −0.957673269 | ||
| 10 | 27361475 | Genebody | − | + | −0.95434547 | |||
| 10 | 27361468 | Genebody | − | + | −0.921209644 | |||
| 10 | 27361450 | Genebody | − | + | −0.960461808 | |||
| PCOLCE | 3 | 7921803 | Genebody | − | + | −0.995207087 | ||
| RAB22A | 17 | 65753356 | Genebody | CGI shore | + | − | −0.884084122 | |
| SLA-7 | 7 | 27608918 | UP10K | + | − | −0.914258584 | ||
| TUBGCP6 | 5 | 110682055 | Genebody | CGI shore | + | − | −0.90531831 | |
| VGLL2 | 1 | 49880654 | Genebody | CGI shore | − | + | −0.753634499 | |
| 1 | 49880666 | Genebody | CGI shore | − | + | −0.805639146 | ||
| XPO4 | 11 | 268954 | Genebody | CGI shore | + | − | −0.909143259 | |
| 11 | 269035 | Genebody | + | − | −0.914121809 | |||
| Spleen | ICAM-1 | 2 | 69496888 | Genebody | CGI shore | − | + | −0.755261243 |
| ALDH3A1 | 12 | 62650896 | UP10K | CGI shore | + | − | −0.788071349 | |
| 12 | 62650898 | UP10K | CGI shore | + | − | −0.752480115 | ||
| KIRREL3 | 9 | 59344774 | Genebody | − | + | −0.957798851 | ||
| GTF2IRD1 | 3 | 11271020 | UP10K | − | + | −0.917047466 | ||
| UBA52 | 2 | 59052151 | UP10K | − | + | −0.953385635 | ||
| CD163 | 14 | 153630638 | Genebody | CGI shore | − | + | −0.860727255 | |
| HMHA1 | 2 | 77641888 | UP10K | CGI shore | + | − | −0.861581753 | |
| RPS21 | 17 | 69165427 | UP10K | CGI shore | − | + | −0.829232698 | |
| 17 | 69165425 | UP10K | CGI shore | − | + | −0.811905734 | ||
| 17 | 69169540 | UP10K | − | + | −0.852778602 | |||
| 17 | 69169556 | UP10K | − | + | −0.743101278 | |||
| SLC9A3R2 | 3 | 42231210 | Genebody | CGI shore | − | + | −0.752184061 | |
| ZNF646 | 3 | 17732629 | Genebody | CGI shore | − | + | −0.828529507 | |
| ADAMTS4 | 4 | 97117737 | Genebody | − | + | −0.802729052 | ||
| 4 | 97117751 | Genebody | − | + | −0.8029031 | |||
| 4 | 97117778 | Genebody | − | + | −0.806509102 | |||
| 4 | 97117512 | UP10K | − | + | −0.763107181 | |||
| 4 | 97117534 | UP10K | − | + | −0.814870957 | |||
| TBKBP1 | 12 | 23838338 | Genebody | − | + | −0.89415394 | ||
| 12 | 23838110 | Genebody | CGI shore | − | + | −0.975048371 | ||
| 12 | 23838349 | Genebody | − | + | −0.821418354 | |||
aChromosome.
bClass represents genomic location of tDMC; exon and intron region, 10 kb upstream region from TSS and CGI Shore were marked as Genebody, UP10K and CGI shore, respectively.
cMethylation pattern, + and − represent higher and lower methylation over other tissues, respectively.
dExpression level, + and − represent higher and lower expression levels over other tissues, respectively.
ePearson's correlation score.