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Estrogen ligands, mouse models, and intimal hyperplasia protocol used in the study. A, Schematic representation of the Tie2Cre+ ERαlox/lox, αSMACreERT2+ ERαlox/lox and ERαAF10/0 mouse model and (B) of the protocol used to evaluate neointimal hyperplasia. C, Mechanism of estrogen receptor α (ERα) activation by 17β-estradiol (E2), estetrol (E4), tamoxifen (Tmx) and estrogen dendrimer conjugate (EDC). CRE indicates Cre recombinase.
