Table 2.
Crude and adjusted hazard ratios with confidence intervals from a Cox model after multiple imputation for all deaths during TB treatment
| Crude | Adjusted | Adjusted (selected by AIC*) | |||
|---|---|---|---|---|---|
| HR (95 % CI) | p value | HR (95 % CI) | p value | HR (95 % CI) | |
| Sex female | 1.05 (0.91–1.20) | 0.51 | 1.08 (0.94–1.24) | 0.28 | |
| Age | |||||
| <25 | Reference | Reference | Reference | ||
| 25–35 | 1.88 (1.42–2.48) | 0.00 | 1.53 (1.15–2.03) | 0.00 | 1.52 (1.14–2.01) |
| 35–45 | 2.37 (1.78–3.14) | 0.00 | 1.93 (1.45–2.58) | 0.00 | 1.90 (1.43–2.53) |
| 45–60 | 3.54 (2.66–4.72) | 0.00 | 3.25 (2.42–4.35) | 0.00 | 3.20 (2.40–4.27) |
| >60 | 6.54 (4.65–9.19) | 0.00 | 7.22 (5.11–10.22) | 0.00 | 7.22 (5.11–10.19) |
| Anatomic site of TB | |||||
| Pulmonary | Reference | Reference | Reference | ||
| Extra-pulmonary | 1.38 (1.18–1.62) | 0.00 | 1.20 (0.99–1.45) | 0.06 | 1.29 (1.10–1.51) |
| Both | 1.62 (1.27–2.06) | 0.00 | 1.45 (1.14–1.85) | 0.00 | 1.46 (1.15–1.86) |
| Prior TB | 1.28 (1.11–1.49) | 0.00 | 1.16 (1.00–1.35) | 0.05 | 1.16 (1.00–1.34) |
| HIV infected | 1.82 (1.51–2.20) | 0.00 | 1.94 (1.58–2.40) | 0.00 | 2.00 (1.63–2.46) |
| TB smear result | |||||
| Smear negative | Reference | Reference | |||
| Smear positive | 0.73 (0.63–0.84) | 0.00 | 0.93 (0.79–1.10) | 0.41 | |
| No smear performed | 1.11 (0.91–1.36) | 0.31 | 1.08 (0.87–1.34) | 0.47 | |
TB tuberculosis, ART antiretroviral treatment, TMP-SMX trimethoprim sulfamethoxazole 160/80 mg chemoprophylaxis, HR hazard ratio, 95 % CI 95 % confidence interval, AIC Akaike information criterion