Table 2.
Comparison of the in vitro biological potency of the amikacin products studied
| Product | Escherichia coli SIG-1 | Pseudomonas aeruginosa ATCC 27853 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MIC | Min | Max | MBC | Min | Max | MIC | Min | Max | MBC | Min | Max | |
| BMS | 1.59 | 1.00 | 2.00 | 1.78 | 1.00 | 2.00 | 4.00 | 4.00 | 4.00 | 10.08 | 8.00 | 16.00 |
| Carlon | 4.00 | 4.00 | 4.00 | 8.00 | 8.00 | 8.00 | 5.66 | 4.00 | 8.00 | 5.66 | 4.00 | 8.00 |
| FormasG | 4.00 | 4.00 | 4.00 | 4.00 | 4.00 | 4.00 | 5.66 | 4.00 | 8.00 | 8.00 | 8.00 | 8.00 |
| Gencol | 2.00 | 2.00 | 2.00 | 2.00 | 2.00 | 2.00 | 4.00 | 4.00 | 4.00 | 8.00 | 4.00 | 16.00 |
| Genven | 2.00 | 2.00 | 2.00 | 2.00 | 2.00 | 2.00 | 2.83 | 2.00 | 4.00 | 5.66 | 4.00 | 8.00 |
| Pisa | 2.00 | 2.00 | 2.00 | 2.83 | 2.00 | 4.00 | 4.00 | 4.00 | 4.00 | 11.31 | 8.00 | 16.00 |
| Quimicol | 2.83 | 1.00 | 8.00 | 4.00 | 2.00 | 8.00 | 3.36 | 2.00 | 4.00 | 6.73 | 4.00 | 16.00 |
| Scalpi | 2.83 | 2.00 | 4.00 | 2.83 | 2.00 | 4.00 | 4.00 | 4.00 | 4.00 | 4.00 | 4.00 | 4.00 |
| Serpharma** | 19.03 | 16.00 | 32.00 | 22.63 | 16.00 | 32.00 | 38.05 | 32.00 | 64.00 | 64.00 | 64.00 | 64.00 |
| Sigma | 1.41 | 1.00 | 2.00 | 2.83 | 2.00 | 4.00 | 4.00 | 4.00 | 4.00 | 8.00 | 8.00 | 8.00 |
| Zokumey | 2.00 | 2.00 | 2.00 | 4.00 | 2.00 | 8.00 | 4.00 | 4.00 | 4.00 | 11.31 | 8.00 | 16.00 |
Concentrations are expressed as geometric mean and range (Min. and Max) in mg/L
MIC minimal inhibitory concentration, MBC minimal bactericidal concentration
** p value <0.05 by Dunn’s multiple comparison test