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. Author manuscript; available in PMC: 2015 Oct 7.
Published in final edited form as: Cell Biochem Biophys. 2013 Nov;67(2):363–372. doi: 10.1007/s12013-011-9332-z

Fig. 2.

Fig. 2

Cell-cycle regulatory proteins in MCT-induced pulmonary hypertension. Western-blot analysis was performed on lung and heart tissues obtained 2 weeks after administration of a single dose of MCT (60 mg/kg). a Representative blots show the downregulation of p53, p21, and p27, and upregulation of cyclin-D1 expression. b Quantitative results of the blots of p53 and cyclin-D1 in the lung, RV, and LV. Data represent mean ± SEM (n = 8). *P < 0.05 versus respective control (C). The results show a significant decrease of p53 and increase of cyclin-D1 in the lung, RV and LV