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. Author manuscript; available in PMC: 2015 Oct 7.
Published in final edited form as: Bioorg Med Chem. 2010 Feb 25;18(8):2954–2963. doi: 10.1016/j.bmc.2010.02.040

Scheme 3. Reagents and conditions.

Scheme 3

(a) NaClO2 (1.1 equiv.), H2O2 (0.9 equiv.), H2O-MeCN, KH2PO4, 0°C, 1 h, r. t., then Na2S2O5, H+; (b) SOCl2 (1.23 equiv.), pyridine (1.25 equiv.), benzene, 0°C, 10 min., then r. t., 40 min.