Skip to main content

View full-text article in PMC

. Author manuscript; available in PMC: 2015 Oct 7.

Published in final edited form as: Bioorg Med Chem. 2010 Feb 25;18(8):2954–2963. doi: 10.1016/j.bmc.2010.02.040

Table 1.

Biological activity of new verapamil derivatives


Compound	R¹	X	Superoxide Scavenging (%)	Peroxyl Scavenging (%)	Cytotoxicity CHO (%)	Cytotoxicity HSMC (%)
1 verapamil	-	-	2.1 ± 4.2^a	60.0 ± 3.5^a	61.03 ± 6.2	55.95 ± 7.87
11B HO-4149		O	100^a 84.2±4.4^b	100^a 98.0±0.5^b	62.1 ± 9.1	40.2 ± 3.8
12A H-3009		O	34.9 ± 2.5 ^a	84.1 ± 3.8^a	53.5 ± 11.0	53.7 ± 4.5
12B H-3010		O	55.2 ± 3.2 ^a	14.9 ± 17.8 ^a	48.9 ± 4.8	59.1 ± 4.5
13B HO-4148		O	100 ^a 78.2±4.9^b	100 ^a 100^b	60.0 ± 3.6	39.7 ± 4.2
14B HO-4099		O	100 ^a 79.3±1.2^b	100 ^a 86.1±0.1^b	68.3 ± 7.4	47.5 ± 3.0
15 HO-4087		O	60.7 ± 0.2 ^a	89.8 ± 1.8 ^a	55.5 ± 8.0	48.7 ± 5.2
16B HO-4038		O	100 ^a 66.5 ± 1.2 ^b	100 ^a 91.4 ± 0.3 ^b	46.1 ± 12.4	33.1 ± 6.9
17B HO-4218		O	100 ^a 76.5±4.3 ^b	90.1 ± 3.4 ^a	50.3 ± 10.4	40.2 ± 3.5
18B HO-4152		O	100^a 70.7±4.3^b	100^a 89.2±0.1^b	54.0 ± 6.4	44.0 ± 6.2
20B HO-3886		H₂	100 ^a 88.5±4.2^b	100 ^a 92.9±1.0^b	63.6 ± 6.5	43.3 ± 7.3
20A HO-3887		H₂	100 ^a 73.8±1.0^b	100 ^a 89.8±3.9^b	71.2 ± 4.1	39.1 ± 4.6

^a

Measured using 1-mM compound in presence of 1-mM DEPMPO

^b

Measured using 100-μM compound in presence of 1-mM DEPMPO