Table 4. Case-control study for the association between TLR single nucleotide polymorphisms and end-stage renal disease per underlying disease category.

Gene	HGVS name	Renal disease	N cases	MAF cases(%)	MAF controls(%)	OR 1	95% CI 1	P-value 2	Type II error when P < 0.05 3
TLR1	p.His305Leu	Congenital	216	10.4	2.6	4.94	2.26–10.84	0.0002	0%
		Glomerulonephritis	299	8.4	2.6	4.91	2.31–10.41	0.0001	0%
		Pyelonephritis	126	11.5	2.6	6.71	3.10–14.53	<0.0001	0%
		Renovascular	102	9.8	2.6	4.37	1.83–10.43	0.003	0%
TLR1	p.Asn248Ser	Congenital	216	25.9	25.9	1.02	0.76–1.37	1
		Glomerulonephritis	299	32.6	25.9	1.33	1.05–1.67	0.05	16%
		Pyelonephritis	126	27.0	25.9	1.27	0.94–1.71	0.4
		Renovascular	102	33.3	25.9	1.53	1.10–2.11	0.03	28%
TLR8	p.Met1Val	Congenital	216	24.6	22.6	1.18	0.86–1.64	0.9
		Glomerulonephritis	299	29.4	22.6	1.52	1.18–1.97	0.004	9%
		Pyelonephritis	126	28.1	22.6	1.24	0.85–1.81	0.8
		Renovascular	102	33.6	22.6	1.86	1.25–2.77	0.002	17%

¹Per allele odds ratios (OR) and 95% confidence intervals (CI) based on additive genetic logistic regression models adjusted for age and gender, taking case-control relatedness into consideration (DFAM algorithm). HGVS = Human Genome Variation Society.

² P-values are Bonferroni corrected.

³ Post hoc estimates of the type II errors (100%–power) were calculated according to the methods by Skol et al. [23] with the data as mentioned in the table and an end-stage renal disease prevalence of 0.1% (estimate in The Netherlands).