Table 5. Association of TLR single nucleotide polymorphism with delayed graft function in univariable logistic regression analysis.
| Gene | HGVS name | Allele combination 1 | Donor | Recipient | ||||
|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | P-value 2 | OR | 95% CI | P-value 2 | |||
| TLR1 | p.His305Leu | T/a | 0.69 | 0.34–1.30 | 1 | 1.12 | 0.75–1.67 | 1 |
| a/a | 2.37 | 0.09–60.01 | 1 | 0.55 | 0.23–1.13 | 1 | ||
| TLR1 | p.Asn248Ser | C/t | 0.86 | 0.65–1.13 | 1 | 0.85 | 0.64–1.12 | 1 |
| t/t | 0.65 | 0.37–1.11 | 1 | 1.64 | 1.07–2.50 | 0.4 | ||
| TLR2 | p.Arg753Gln | G/a | 0.71 | 0.44–1.11 | 1 | 0.74 | 0.52–1.04 | 1 |
| a/a | - | - | - | - | - | - | ||
| TLR4 | p.Asp299Gly | A/g | 1.30 | 0.86–1.94 | 1 | 0.82 | 0.53–1.24 | 1 |
| g/g | 2.48 | 0.10–62.79 | 1 | 1.18 | 0.05–12.33 | 1 | ||
| TLR4 | p.Thr399Ile | C/t | 1.28 | 0.85–1.90 | 1 | 0.85 | 0.56–1.28 | 1 |
| t/t | - | - | - | 1.18 | 0.05–12.37 | 1 | ||
| TLR5 | p.Arg392Ter | G/a | 1.35 | 0.94–1.93 | 1 | 1.08 | 0.75–1.54 | 1 |
| a/a | - | - | - | 1.46 | 0.30–6.00 | 1 | ||
| TLR5 | p.Phe616Leu | A/g | 0.92 | 0.69–1.24 | 1 | 0.78 | 0.59–1.05 | 1 |
| g/g | 1.15 | 0.80–1.67 | 1 | 0.88 | 0.60–1.28 | 1 | ||
| TLR6 | p.Ser249Pro | G/a | 1.00 | 0.75–1.33 | 1 | 0.91 | 0.68–1.20 | 1 |
| a/a | 0.97 | 0.66–1.41 | 1 | 1.01 | 0.69–1.46 | 1 | ||
| TLR7 | p.Gln11Leu | A/t | 0.88 | 0.63–1.23 | 1 | 0.83 | 0.57–1.19 | 1 |
| t/t | 1.25 | 0.83–1.85 | 1 | 0.74 | 0.48–1.09 | 1 | ||
| TLR8 | p.Met1Val | A/g | 0.96 | 0.68–1.34 | 1 | 1.09 | 0.77–1.55 | 1 |
| g/g | 1.04 | 0.70–1.53 | 1 | 1.12 | 0.80–1.54 | 1 | ||
OR = odds ratio (1per allele combination as compared to the homozygous dominant allele combination)
CI = confidence interval, HGVS = Human Genome Variation Society. The results represent univariable crude models, i.e. no other independent variables were included.
2 P-values are Bonferroni corrected.