Table 7. Association of TLR single nucleotide polymorphism with death-censored graft survival.
| Gene | HGVS name | Allele combination 1 | Donor | Recipient | ||||
|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | P-value 2 | HR | 95% CI | P-value 2 | |||
| TLR1 | p.His305Leu | T/a | 1.02 | 0.52–2.00 | 1 | 1.01 | 0.65–1.56 | 1 |
| a/a | - | - | 0.56 | 0.23–1.37 | ||||
| TLR1 | p.Asn248Ser | C/t | 1.13 | 0.84–1.52 | 1 | 1.11 | 0.82–1.50 | 1 |
| t/t | 0.93 | 0.51–1.69 | 1.44 | 0.92–2.24 | ||||
| TLR2 | p.Arg753Gln | G/a | 1.13 | 0.72–1.77 | 1 | 1.29 | 0.93–1.80 | 1 |
| a/a | - | - | - | - | ||||
| TLR4 | p.Asp299Gly | A/g | 1.15 | 0.74–1.80 | 1 | 0.80 | 0.50–1.29 | 1 |
| g/g | - | - | - | - | ||||
| TLR4 | p.Thr399Ile | C/t | 1.17 | 0.76–1.81 | 1 | 0.74 | 0.45–1.20 | 1 |
| t/t | - | - | - | - | ||||
| TLR5 | p.Arg392Ter | G/a | 1.31 | 0.90–1.90 | 1 | 0.84 | 0.55–1.27 | 1 |
| a/a | - | - | 0.77 | 0.11–5.52 | ||||
| TLR5 | p.Phe616Leu | A/g | 1.03 | 0.75–1.43 | 1 | 1.20 | 0.87–1.64 | 1 |
| g/g | 0.82 | 0.53–1.28 | 0.70 | 0.44–1.13 | ||||
| TLR6 | p.Ser249Pro | G/a | 1.19 | 0.87–1.64 | 1 | 0.85 | 0.62–1.17 | 1 |
| a/a | 0.96 | 0.62–1.48 | 1.08 | 0.73–1.61 | ||||
| TLR7 | p.Gln11Leu | A/t | 0.83 | 0.57–1.19 | 1 | 0.89 | 0.59–1.35 | 1 |
| t/t | 0.96 | 0.61–1.50 | 1.41 | 0.96–2.06 | ||||
| TLR8 | p.Met1Val | A/g | 0.99 | 0.68–1.44 | 1 | 1.05 | 0.71–1.56 | 1 |
| g/g | 1.20 | 0.80–1.80 | 1.28 | 0.91–1.82 | ||||
HR = hazard ratio (1per allele combination as compared to the homozygous dominant allele combination)
CI = confidence interval, HGVS = Human Genome Variation Society. The results represent univariable crude models, i.e. no other independent variables were included.
2 P-values are calculated by log rank tests after Bonferroni correction for multiple comparisons.