Table 2.
Association between SNPs of candidate genes and severity of EV71 infection
| Candidate polymorphisms | Genotypes | Cases | Control (N = 57) | OR (95% CI)* | P value* | |
|---|---|---|---|---|---|---|
| Complication patients (N = 48) | Encephalitis patients (N = 39) | |||||
| CCL5 -403G/A | GG | 19 (39.6) | 17 (43.6) | 33 (57.9) | 1.000 (ref.) | – |
| – | GA + AA | 29 (60.4) | 22 (56.4) | 24 (42.1) | 2.032 (1.054–3.918) | 0.034 |
| CCL5 -28C/G | CC | 38 (79.2) | 28 (79.8) | 48 (84.2) | 1.000 (ref.) | – |
| – | CG + GG | 10 (20.8) | 11 (28.2) | 9 (15.8) | 1.198 (0.544–2.640) | 0.653 |
| CCL5 In1.1T/C | TT | 21 (43.8) | 17 (43.6) | 33 (57.9) | 1.000 (ref.) | – |
| – | TC + CC | 27 (56.2) | 22 (56.4) | 24 (42.1) | 1.781 (0.927–3.419) | 0.083 |
CCL5 = chemotactic chemokine ligand 5; CI = confidence interval; EV 71 = Enterovirus 71; OR = odds ratio; SNPs = single-nucleotide polymorphisms.
For results shown in bold, P < 0.05. Dependent variables were categorized as encephalitis patients with complications, encephalitis patients and asymptomatic controls. Three models were fitted for the SNPs of candidate genes as independent variables separately.
*
P values and ORs are adjusted for age by ordinal logistic regression analysis.