Table 5. Association of patient and tumor characteristics with unfavorable prognosis: univariate and multivariate analysis.
| Unfavorable prognosis N (%) | Favorable prognosis N (%) | Pvalue* | Multivariate Odds Ratio (95%CI) | Pvalue | |
|---|---|---|---|---|---|
| Volume^ | 49.08 (±10.01) | 47.70 (±15.33) | 0.20 | 1.01 (0.97–1.05) 2 | 0.74 |
| Age^ | 65.36 (±7.80) | 62.19 (±8.29) | 0.01 | 1.04 (0.98–1.10) 2 | 0.26 |
| Clinical Stage | 0.03 | 0.04 | |||
| cT1c | 29 (74%) | 162 (88%) | 1.00 (reference) | ||
| cT2a | 10 (26%) | 22 (12%) | 2.96 (1.06–8.22) | ||
| PSA^ | 6.87 (±2.08) | 5.84 (±1.83) | 0.002 | 1.36 (1.08–1.72) 2 | 0.01 |
| PSA Density^ | 0.14 (±0.04) | 0.13 (±0.04) | 0.04 | - 3 | - |
| Positive Cores | 0.38 | 0.98 | |||
| 1 | 14 (36%) | 81 (44%) | 1.00 (reference) | ||
| 2 | 25 (67%) | 103 (56%) | 1.01 (0.43–2.37) | ||
| PIRADS | <0.0001 1 | 5.42 (2.74–10.70) 2 | <0.0001 | ||
| 1 | 0 (0%) | 2 (1%) | |||
| 2 | 0 (0%) | 14 (8%) | |||
| 3 | 0 (0%) | 58 (32%) | |||
| 4 | 11 (28%) | 60 (33%) | |||
| 5 | 28 (72%) | 47 (26%) | |||
| Cancer at MRI | 0.05 | - 3 | - | ||
| Not visible | 0 (0%) | 19 (10%) | |||
| Visible | 39 (100%) | 165 (90%) |
1Mantel-Haenszel p-value for trend = <0.0001
*T test or non parametric two-sample Wilcoxon test for continuous variables, as appropriate; Chi-Square test or Fisher’s Exact Test for categorical variables, as appropriate
2One-unit increase OR
3Not entered in the multivariate model because it is a linear combination of other variables.
Note: significant ORs and p-values are in bold.