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. 2015 Oct 2;201(2):377–402. doi: 10.1534/genetics.115.179457

Figure 8.

Figure 8

Fly studies highlighting interactions with PABP led to testing for PABPC1 mislocalization in motor neurons of ALS patient tissue. Fly data suggested that PABP may be involved in ALS; here human patient tissue was examined to assess that possibility. (A–D) Immunostaining for PABPC1 (cytoplasmic PABP) of spinal cord motor neurons in control and ALS patients. PABPC1 is present and localized throughout the cytoplasm in normal motor neurons, but shows striking accumulation in motor neurons of patients with ALS. Bars, 30 µm. (E) Quantitation of the accumulations [reprinted from Kim et al. (2014)].