Table 2. Relaxivity properties of SPIONs with/without plasma corona.
| Particles | r1 (s-1 mM-1) a | r2 (s-1 mM-1) a | r2/ r1 | |||
|---|---|---|---|---|---|---|
| 20 MHz | 60 MHz | 20 MHz | 60 MHz | 20 MHz | 60 MHz | |
| CSNP | 1.43 (±0.04) | 0.74 (±0.02) | 27.38 (±0.1) | 32.22 (±0.1) | 19.14 | 43.54 |
| CSNP@protein corona | 0.90 (±0.02) | 0.47 b | 30.15 (±0.2) | 32.44 b | 33.5 | 69.02 |
| Nanomag-D-spio | 17.86 (±0.1) | 7.14 (±0.1) | 65.57 (±0.2) | 72.11 (±0.1) | 3.67 | 10.09 |
| Nanomag-D-spio@protein corona | 21.87 (±0.2) | 7.76 (±0.1) | 83.64 (±0.1) | 85.79 (±0.3) | 3.82 | 11.05 |
Relaxivity values are measured at 20 MHz (0.47 T) and 60 MHz (1.41 T) in PBS (37°C).
aResults presented as mean values ± SD, n = 3.
bCSNP@protein corona particles are unstable over the measurements time at 60 MHz.