Table 3. Most abundant CSNP nanoparticle enriched proteins.
| UNIPROT | AAs | MW.kDa. | calc. pI | SYMBOL | GENENAME | log2 FC | CSNP | Nmag | Plasma | FDR q‐ value |
|---|---|---|---|---|---|---|---|---|---|---|
| P02675 | 491 | 55.9 | 8.27 | FGB | fibrinogen beta | 2.19 | 11.2% | 0.4% | 0.8% | 2.7E‐02 |
| P02679 | 437 | 49.5 | 6.09 | FGG | fibrinogen gamma | 1.72 | 9.8% | 0.2% | 0.7% | 2.0E‐04 |
| P02671 | 644 | 69.7 | 8.06 | FGA | fibrinogen alpha | 1.94 | 9.6% | 0.2% | 0.6% | 4.3E‐04 |
| P04004 | 478 | 54.3 | 5.8 | VTN | vitronectin | 1.68 | 5.8% | 1.5% | 0.5% | 6.7E‐02 |
| P04196 | 525 | 59.5 | 7.5 | HRG | histidine‐rich glycoprotein | 3.65 | 5.1% | 1.7% | 0.1% | 5.8E‐04 |
| P07996 | 1170 | 129.3 | 4.94 | THBS1 | thrombospondin 1 | 6.31 | 2.9% | 1.3% | 0.0% | 4.0E‐06 |
| Q9HC10 | 1230 | 140.2 | 6.24 | OTOF | otoferlin | 1.48 | 1.9% | 0.0% | 0.0% | 1.7E‐01 |
| P00748 | 615 | 67.7 | 7.74 | F12 | coagulation factor XII | 5.54 | 1.7% | 0.0% | 0.0% | 1.2E‐01 |
| P0C0L4 | 1744 | 192.7 | 7.08 | C4A/C4B | complement 4A / 4B | 1.48 | 1.7% | 0.5% | 0.4% | 7.6E‐01 |
| Q03591 | 330 | 37.6 | 7.39 | CFHR1 | complement factor H‐ related 1 | 4.42 | 1.3% | 0.0% | 0.0% | 1.1E‐01 |
| P02751 | 2176 | 239.5 | 5.88 | FN1 | fibronectin 1 | 3.37 | 1.2% | 0.2% | 0.1% | 6.5E‐01 |
| P00734 | 622 | 70 | 5.9 | F2 | coagulation factor II | 2.06 | 1.0% | 0.0% | 0.3% | 7.9E‐03 |
| Q76FK4 | 1041 | 117.4 | 6.92 | NOL8 | nucleolar protein 8 | 1.48 | 0.9% | 0.0% | 0.0% | 2.0E‐01 |
| P00747 | 810 | 90.5 | 7.24 | PLG | plasminogen | 1.56 | 0.7% | 0.4% | 0.3% | 2.0E‐03 |
| P02649 | 317 | 36.1 | 5.73 | APOE | apolipoprotein E | 3.77 | 0.7% | 0.1% | 0.1% | 2.0E‐01 |
| P59665 | 94 | 10.2 | 6.99 | DEFA1 | defensin, alpha 1/1B | 4.19 | 0.6% | 0.2% | 0.0% | 1.8E‐05 |
| P04114 | 4563 | 515.3 | 7.05 | APOB | apolipoprotein B | 2.06 | 0.5% | 0.0% | 0.1% | 1.0E‐01 |
| P02747 | 245 | 25.8 | 8.41 | C1QC | complement 1qC | 3.49 | 0.5% | 0.2% | 0.0% | 1.3E‐04 |
Uniprot = Uniprot accession, AAs = Number of Amino acids in the protein, MW.kDa. = molecular weight of the protein (calculated), calc.pI = protein isoelectric point (calculated), Symbol = Official gene symbol, GeneName = Official gene name, log2FC = log2 transformed fold‐change relative to plasma, CSNP% = relative abundance of the protein in the CSNP corona, Nmag% = NMag abundance, Plasma% = plasma abundance, FDR q‐value = false discovery rate corrected p‐value for the difference relative to plasma, CSNP = core shell nano particles; Nmag = nanomag‐D‐spio. Plasma = crude plasma (control).