Table 1.

MiRNA deregulation with respect to affected hallmarks of cancer capabilities

Hallmarks of Cancer
	Sustaining Proliferative Signaling	Evading Growth Suppressors	Resisting Cell Death	Enabling Replicative Mortality	Inducing Angiogenesis	Activating Invasion and Metastasis	Genome Instability and Mutation	Tumor Promoting Inflammation
↑	miR-7	miR-195	miR-290–295		miR-1908	miR-214		miR-29
	miR-17	miR-221			miR-199a-5p			miR-21
	miR-18	miR-222			miR-199a-3p
	miR-19
	miR-92a
	miR-106b ∼ 25
	miR-222
↓	miR-let7	miR-18b	miR-18b	miR-34a		miR-let-7a	miR-let-7a†
	miR-10		miR-26a	miR-203		miR-9	miR-let-7b
	miR-22		miR-137	miR-205		miR-137	miR-18b
	miR-26a		miR-193b	miR-125b		miR-148	miR-146a*
	miR-30		miR-205			miR-182	miR-193b
	miR-34					miR-196a	miR-203
	miR-125a					miR-211	miR-205
	miR-137					miR-340
	miR-193b					miR-573
	miR-205
	miR-211

The lists of the microRNAs (miRNA, miR) here are those discussed in this paper and are not meant to be a comprehensive list. Up and down arrows indicate up- and downregulation of miRNA in melanoma.

^*The miRNA is mutated in melanoma, resulting in decreased expression of this miRNA. †A mutation has been reported in the KRAS gene located in the binding site of this miRNA, which allowed this KRAS variant to escape the regulation of this miRNA.