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. Author manuscript; available in PMC: 2015 Oct 7.
Published in final edited form as: Cancer Immunol Res. 2015 May 26;3(10):1158–1164. doi: 10.1158/2326-6066.CIR-15-0043

Figure 2. PD-L1 positivity is detected in high-grade tumor areas.

Figure 2

a. Representative images of a primary ccRCC tumor with heterogeneous PD-L1 expression. Membranous expression of PD-L1 in tumor cells is negative in low nuclear grade areas (A) but present in high nuclear grade areas (B). Scale bar: 50 µm. b. Graphic representation of PD-L1 status in distinct nuclear grade areas within primary and metastatic lesions from PD-L1-positive cases. The height of each bar indicates the number of lesions that contain a given tumor grade component (i.e. Grade 1, Grade 2, Grade 3, Grade 4). PD-L1 positivity is indicated in red and PD-L1 negativity is indicated in blue.