Table #1.
Overall Baseline Characteristics of Cohort (n=2252)
| Males (n=842) | Females (n=1,397) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Q1 PASE | Q2 PASE | Q3 PASE | Q4 PASE | P-value | Q1 PASE | Q2 PASE | Q3 PASE | Q4 PASE | P-value | |
| <97 N=214 | 98-144 N=210 | 145-187 N=209 | >188 N=209 | <85 N=355 | 86-124 N=347 | 125-170 N=351 | >171 N=344 | |||
| Age | 70.1 ± 5.3 | 69.9±5.2 | 68.8±4.9 | 66.8±5.3 | <0.001 | 68.8±5.6 | 68.4±5.2 | 67.7±5.1 | 65.8±4.9 | <0.001 |
| Education Status | ||||||||||
| < High School | 44 (20.8) | 27 (12.9) | 32 (14.4) | 18 (8.6) | 88 (24.8) | 91 (25.6) | 71 (20.0) | 105 (29.6) | ||
| Some College | 33 (15.6) | 31 (14.8) | 33 (15.9) | 41 (19.6) | 0.04 | 87 (25.1) | 90 (25.9) | 68 (19.6) | 102 (29.4) | 0.02 |
| College | 42 (19.8) | 55 (26.2) | 40 (19.2) | 54 (25.8) | 78 (22.4) | 108 (31.0) | 52 (14.9) | 110 (31.6) | ||
| >College | 93 (43.9) | 97 (46.2) | 103 (49.5) | 96 (45.9) | 65 (19.1) | 113 (33.1) | 42 (12.3) | 121 (35.5) | ||
| Yearly Income | ||||||||||
| >$50,000 | 121 (58.7) | 135 (65.9) | 127 (64.8) | 147 (72.4) | 0.04 | 147 (43.9) | 144 (43.5) | 150 (45.3) | 172 (55.0) | 0.01 |
| Marital Status | ||||||||||
| Married | 166 (78.3) | 175 (83.3) | 165 (79.3) | 176 (84.2) | 0.32 | 181 (51.1) | 209 (60.2) | 209 (60.1) | 196 (57.5) | 0.05 |
| Race | ||||||||||
| White | 165 (77.1) | 190 (90.5) | 182 (87.1) | 187 (89.5) | 248 (70.1) | 279 (80.4) | 299 (85.2) | 287 (83.4) | ||
| Black | 42 (19.6) | 16 (7.6) | 25 (12.0) | 15 (7.2) | 0.002 | 93 (26.3) | 63 (18.2) | 46 (13.1) | 45 (13.1) | <0.001 |
| Asian | 3 (1.4) | 1 (0.5) | 1 (0.5) | 1 (0.5) | 8 (2.3) | --- | 3 (0.9) | 3 (0.9) | ||
| Charlson Score | 0.60 ± 1.08 | 0.60 ± 1.05 | 0.53 ± 0.99 | 0.54 ± 1.08 | <0.001 | 0.46±0.88 | 0.41±0.85 | 0.37±0.70 | 0.28±0.67 | 0.03 |
| Baseline WOMAC Right | 10.9 ± 12.5 | 9.2 ± 12.0 | 8.2 ± 11.0 | 8.9 ± 11.2 | 0.007 | 15.4 ± 16.9 | 12.9±15.6 | 10.9±13.1 | 10.9±13.0 | <0.001 |
| Baseline WOMAC Left | 11.7 ± 15.0 | 9.8±13.3 | 7.9±12.7 | 8.8 ± 13.5 | 0.03 | 14.5±17.3 | 11.7±15.3 | 10.0±13.8 | 11.1±14.5 | 0.001 |
| Ever Smoker | 115 (54.3) | 123 (58.9) | 111 (54.4) | 111 (53.4) | 0.67 | 166 (47.2) | 153 (44.5) | 175 (50.9) | 159 (46.8) | 0.41 |
| # Medications | 4.24 ± 2.77 | 3.79 ± 2.41 | 3.63 ± 2.30 | 3.32 ± 2.20 | 0.004 | 4.29±2.56 | 3.88±2.41 | 3.66±2.40 | 3.50±2.33 | <0.001 |
| Body mass index | 28.9±3.7 | 28.8±4.1 | 28.6±4.0 | 28.3±3.7 | 0.46 | 29.0±5.3 | 27.9±4.8 | 27.5±4.5 | 27.8±4.8 | <0.001 |
| Maximum Knee Extensor strength (N) | 411.2±108.9 | 424.1±107.1 | 434.2±109.0 | 463.0±110.8 | <0.001 | 262.4±82.2 | 283.4±77.3 | 284.3±73.5 | 302.5±77.7 | <0.001 |
| Cohort Allocation | ||||||||||
| Incidence | 143 (66.8) | 153 (72.9) | 153 (73.2) | 150 (71.8) | 235 (66.2) | 256 (73.8) | 270 (76.9) | 262 (76.2) | ||
| Progression | 69 (32.2) | 54 (25.7) | 50 (23.9) | 53 (25.4) | 0.31 | 118 (33.2) | 91 (26.2) | 76 (21.7) | 76 (22.1) | 0.001 |
| Control | 2 (0.93) | 3 (1.4) | 6 (2.9) | 6 (2.9) | 2 (0.6) | -- | 5 (1.4) | 6 (1.7) | ||
All values are represented as mean ± standard deviation, or count (%).
Abbreviations: BMI – body mass index; Q – quartile; WOMAC – Western Ontario McMaster Universities Arthritis Index
p-values represent analysis of variance between four quartile categories in each sex
At baseline, there were 13 subjects without baseline PASE scores