. 2015 Oct 7;10(10):e0139632. doi: 10.1371/journal.pone.0139632

Table 2. Association between SNPs and the longitudinal changes from normal to overweight/obesity (BMI ≥25) in the adult (HUNT2 to HUNT3) and the adolescent to adult subsamples (Young-HUNT1 to HUNT3).

					HUNT2→HUNT3
					cases: 740, controls: 120
Sample	SNP	Gene	Ref. allele/ other allele	OR	L95	U95	P	P^a
Combined	rs560887	G6PC2	A/G	0.90	0.78	1.05	0.18 ^b	1.00
Male				1.12	0.89	1.41	0.35	1.00
Female				0.78	0.65	0.96	0.01	0.36
Combined	rs2075356	GHRL	C/T	0.91	0.73	1.13	0.37 ^b	1.00
Male				0.61	0.43	0.88	8.0x10 ^-3	0.16
Female				1.13	0.86	1.49	0.37	1.00
Combined	rs268	LPL	G/A	1.58	1.06	2.34	0.02	0.47
Male				1.77	0.88	3.54	0.11	0.96
Female				1.49	0.92	2.42	0.11	0.95
Combined	rs4929984	H19	A/C	0.86	0.75	0.98	0.02	0.41
Male				0.88	0.71	1.07	0.20	1.00
Female				0.85	0.72	1.00	0.05	0.79
Combined	rs4074134	BDNF	A/G	0.84	0.71	0.99	0.04	0.64
Male				0.83	0.64	1.07	0.15	0.99
Female				0.86	0.69	1.06	0.16	0.99
Combined	rs10838738	MTCH2	G/A	1.17	1.02	1.34	0.03	0.56
Male				1.16	0.92	1.44	0.21	1.00
Female				1.20	1.00	1.43	0.05	0.79
Combined	rs6277	DRD2	C/T	0.79	0.69	0.90	3.9x10 ^-4	0.02
Male				0.82	0.67	1.00	0.05	0.72
Female				0.77	0.65	0.92	3.3x10^-3	0.07
					Young-HUNT1→HUNT3
					cases: 553 controls: 827
Combined	rs1121980	FTO	T/C	1.27	1.09	1.49	3.0x10 ^-3 ^b	0.04
Male				1.06	0.84	1.32	0.63	1.00
Female				1.53	1.23	1.91	1.8x10 ^-4	<0.01
Combined	rs17782313	MC4R	C/T	1.21	1.02	1.44	0.03	0.22
Male				1.16	0.91	1.49	0.22	0.89
Female				1.26	0.98	1.63	0.07	0.51

In the adult sample, cases (n = 740) were defined with normal weight at HUNT2 and overweight at HUNT3 while controls (n = 1209) were defined as normal weight both at HUNT2 and HUNT3. Overweight at adolescents were assumed according to Cole et al (2001). Cases were defined as normal weight at Young-HUNT1 and overweight (BMI ≥25) at HUNT3 while controls were defined as normal weight both at Young-HUNT1 and HUNT3. All measures were age adjusted and combined samples were additionally sex-adjusted. Empirical P-values were corrected for multiple testing by 1000 permutations.

P^a—P-values after multiple testing. Only results with a nominal significant P-value (P<0.05, underlined) at any of the measures included are shown. Significant results after multiple testing are shown in bold.

^bSex interaction P<0.05.