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. 2014 Oct 23;32(11):3458–3469. doi: 10.1007/s11095-014-1536-7

Table V.

Clinical Summary of huC242 ADCs

Antibody Payload Linker Schedule MTD (mg/m2) T1/2 (hours) DLT Clinical Phase
huC242 DM1 SPP Q1W 115 13–41 Elevated hepatic transaminase I
huC242 DM1 SPP Q3W 235 18–48.5 Elevated hepatic transaminase I
huC242 DM4 SPDB Q3W 168 60–120 Reversible ocular toxicity I
huC242 DM4 SPDB Q3W 168 N/A Reversible ocular toxicity II