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. 2015 Oct 8;8:61. doi: 10.3389/fnmol.2015.00061

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Copyright © 2015 Leheste and Torres.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic diagram depicts the effect of MT1/GPR50 heterodimer formation on PLC signaling events. Whereas MT1/MT1 G protein-coupled transmembrane homodimers are able to transduce photoperiodic information via the activated α subunit of a trimeric (αβγ) G protein Gαq to PLC, MT1/GPR50 heterodimers are unable to bind melatonin and remaining inactive. The balance of active vs. inactive transmembrane melatonin receptors is dependent on the transcriptional activity of gpr50 governed by SIRT1 and resveratrol stimulus.