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. 2015 Sep 24;13(1):183–195. doi: 10.1016/j.celrep.2015.08.065

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© 2015 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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NKX2-5 Acts as an Activator and a Repressor

(A) Four-chambered view comparing hearts from hypomorphic embryos to controls using high-resolution episcopic microscopy. At E11.5, no obvious morphological defect can be detected. At E14.5, hearts from hypomorphic embryos present ventricular septal defect (star) and thinning of the compact layer ventricular free wall (compare red size bar).

(B) Venn diagram depicts the overlap between NKX2-5-enriched region-associated genes (white) and genes downregulated (gray) and upregulated (red) in the heart of hypomorphic embryo.

(C) Most enriched biological processes in the direct target genes list are shown.

(D) Direct targets are categorized by expression pattern as AVC specific or working myocardium. n.s., non-significant; ^∗∗p < 0.002, ^∗p < 0.0489 according to two-tailed Fisher’s exact test. See also Figure S4D.