Table II. List of markers demonstrating good correlation between FF and FFPE tumor tissues. Significant correlations between RPPA signals from FF and FFPE tumor tissue samples were seen for 25 markers after multiple testing correction (Bonferroni corrected alpha = 0.00017) and for an additional 35 markers at the uncorrected level.
| Analyte | Correlation | p value |
|---|---|---|
| A. 25 markers showing significance at the corrected level | ||
| Collagen IA2 | 0.953 | <0.0001 |
| p70S6 kinase-P-Thr389 | 0.936 | <0.0001 |
| c-Jun-P-Ser63 | 0.925 | <0.0001 |
| Cyp2e1 | 0.925 | <0.0001 |
| CEA | 0.888 | <0.0001 |
| IkappaB alpha | 0.888 | <0.0001 |
| HSF1-P-Ser326 | 0.873 | <0.0001 |
| Vimentin | 0.871 | <0.0001 |
| BCRP (ABCG2) | 0.864 | <0.0001 |
| Bim | 0.862 | <0.0001 |
| DUSP4 | 0.858 | <0.0001 |
| p53 | 0.853 | <0.0001 |
| Survivin | 0.838 | <0.0001 |
| c-Met | 0.838 | <0.0001 |
| Connexin43 | 0.837 | <0.0001 |
| Bad-P-Ser112 | 0.836 | <0.0001 |
| Cytokeratin5 | 0.835 | <0.0001 |
| Akt-P-Ser473 | 0.833 | <0.0001 |
| beta-Actin | 0.831 | <0.0001 |
| Bcl-xL | 0.808 | <0.0001 |
| Rb | 0.803 | <0.0001 |
| HSP27 | 0.796 | <0.0001 |
| CD44variant (Exon v6) | 0.778 | <0.0001 |
| STAT1 | 0.777 | <0.0001 |
| Caseinkinase1 delta | 0.748 | 0.0002 |
| B. 35 additional markers showing significance at the uncorrected level | ||
| Caspase9 | 0.741 | 0.0002 |
| alpha1-Actin | 0.738 | 0.0002 |
| Aurora A | 0.732 | 0.0002 |
| Jak1 | 0.722 | 0.0003 |
| Dematin | 0.718 | 0.0004 |
| Aldh1A1 | 0.716 | 0.0004 |
| alpha-Tubulin | 0.711 | 0.0004 |
| Integrin alpha5 | 0.706 | 0.0005 |
| MKK4 | 0.702 | 0.0006 |
| Connexin26 | 0.696 | 0.0006 |
| S6 Ribosomal Protein-P-Ser240/244 | 0.687 | 0.0008 |
| Okt-4 | 0.687 | 0.0008 |
| Cytokeratin16 | 0.681 | 0.0010 |
| eIF2alpha | 0.675 | 0.0011 |
| CyclinD1 | 0.670 | 0.0012 |
| LAMP1 | 0.665 | 0.0014 |
| HDAC6 | 0.652 | 0.0019 |
| 4E-BP1 | 0.643 | 0.0022 |
| Erk1/2-P-Thr202/Tyr204 | 0.641 | 0.0023 |
| Her2-P-Tyr1248 | 0.639 | 0.0024 |
| Cyp3a4, 3a1, 3a11 | 0.637 | 0.0025 |
| MAP2-B-250 | 0.623 | 0.0034 |
| PAK2 | 0.617 | 0.0037 |
| P-Glycoprotein (MDR1, ABCB1) | 0.606 | 0.0046 |
| IGF1 Receptor | 0.599 | 0.0052 |
| RSK1/2/3 | 0.598 | 0.0053 |
| Tubulin-ac | 0.596 | 0.0055 |
| MKK6 | 0.591 | 0.0060 |
| DUSP16 | 0.584 | 0.0069 |
| MDM2 | 0.583 | 0.0070 |
| p27 | 0.582 | 0.0070 |
| NF-κB | 0.574 | 0.0082 |
| Caspase7 | 0.571 | 0.0086 |
| Caspase8 | 0.569 | 0.0089 |
| S6 Ribosomal Protein-P-Ser235/236 | 0.569 | 0.0089 |