Figure 4.

The HLA sequence difference across the modules colored by residue category. HLA sequences from seven major modules are shown. Each line is an HLA partial sequence (residues 2 to 182 on Chain A) of the peptide-binding region. Each column represents a residue at the same position across all the HLAs. For each column, if a residue has their highest frequency within the column, it is not shown (white color). Otherwise, it is colored according to the three categories as explained in the legend to Figure 3.