Table 5. Factors associated with HIV RNA ≥ 1000 copies/ml after switching to second-line therapy for 12 months among patients with viral load >1000 copies/ml at baseline.
| Variable | Number | HIV RNA ≥ 1000 copies/mlN(%) | Crude OR(95% CI) | P-value | Adjusted OR(95% CI) | P-value |
|---|---|---|---|---|---|---|
| Total | 82 | 36(43.9) | ||||
| Age (year) | ||||||
| ≤50 | 23 | 14(60.9) | ||||
| >50 | 59 | 22(37.3) | 0.38(0.14, 1.03) | 0.0569 | ||
| Sex | ||||||
| Female | 46 | 18(39.1) | ||||
| Male | 36 | 18(50.0) | 1.56(0.64, 3.78) | 0.3260 | ||
| Marital status | ||||||
| Other | 10 | 4(40.0) | ||||
| Married | 72 | 32(44.4) | 1.20(0.31, 4.62) | 0.7909 | ||
| HIV transmission route | ||||||
| Other | 7 | 4(57.1) | ||||
| Blood donation | 75 | 32(42.7) | 0.56(0.12, 2.67) | 0.4653 | ||
| HCV antibody test | ||||||
| Negative | 15 | 5(33.3) | ||||
| Positive | 67 | 31(46.3) | 1.72(0.53, 5.58) | 0.3650 | ||
| DDI-based initial ART regimen | ||||||
| No | 25 | 8(32.0) | ||||
| Yes | 57 | 28(49.1) | 2.05(0.76, 5.51) | 0.1539 | 3.45(1.08, 10.98) | 0.0362 |
| Drug resistance before switching to second ART | ||||||
| No | 27 | 13(48.1) | ||||
| Yes | 55 | 23(41.8) | 0.77(0.31, 1.95) | 0.5876 | ||
| Stop the regimen in the past month | ||||||
| No | 78 | 33(42.3) | ||||
| Yes | 4 | 3(75.0) | 4.09(0.41, 41.10) | 0.2314 | ||
| Missed doses in the past month | ||||||
| No | 52 | 16(30.8) | ||||
| Yes | 30 | 20(66.7) | 4.50(1.72, 11.76) | 0.0022 | 4.61(1.58, 13.4) | 0.0051 |
| Always/often get social and emotional support | ||||||
| No | 33 | 21(63.6) | ||||
| Yes | 49 | 15(30.6) | 0.25(0.01, 0.64) | 0.0038 | ||