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. 2015 Sep;185(9):2390–2401. doi: 10.1016/j.ajpath.2015.05.015

Figure 3.

Figure 3

Different serotypes of lipopolysaccharide (LPS) induce variable expression of proinflammatory and procontractile genes in mouse myometrium. Dams were sacrificed at 6 hours after intrauterine injection, and tissue was harvested for real-time quantitative RT-PCR analysis of procontractile and inflammatory genes associated with labor onset, including cyclooxygenase 2 (Cox-2; A), Cx-43 (B), tumor necrosis factor-α Tnf-α (C), Il-1β (D), Il-6 (E), Il-8 (F), matrix metalloproteinase 3 (Mmp3; G), Mmp10 (H), and inducible nitric oxide synthase (iNOS; I) mRNA. Data are presented relative to β-actin mRNA levels. n = 5 (A–I). ∗P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001, versus phosphate-buffered saline (PBS)–injected control dams; †P < 0.05, ††P < 0.01, within LPS treatment group (one-way analysis of variance with Tukey's post hoc analysis).