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. 2015 Sep;185(9):2390–2401. doi: 10.1016/j.ajpath.2015.05.015

Figure 6.

Figure 6

Effect of different lipopolysaccharide (LPS) serotypes on inflammatory gene expression in the fetal brain tissue. Expression of the mRNA of inflammatory genes, Il-8 (A), Il-6 (B), Il-1β (C) Tnf-α (D), neutropic factors including glial fibrillary acidic protein (Gfap E), proteolipid protein (Plp F), inducible nitric oxide synthase (iNOS; G), and endothelial Nos (Nos3; H), was assessed by real-time quantitative RT-PCR in fetal brain tissue collected 6 hours after surgery from mice injected with either phosphate-buffered saline (PBS) or LPS (serotypes O111:B4, O55:B5, O127:B8, or O128:B12). Data are presented relative to β-actin mRNA levels. n = 5 (A–H). ∗P < 0.05, ∗∗P < 0.01 (one-way analysis of variance with Tukey's post hoc test).