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Twice-daily (BID) dosing of GW766994X results in better efficacy in inhibiting spontaneous choroidal neovascularization (CNV) development. Inhibition of CNV development in JR5558 mice is seen on fluorescein angiography (FFA) analysis (A and B) and by immunohistochemical (IHC) analysis of the eye cups (C and D). Data are expressed as means ± SEM. ∗∗P < 0.01, ∗∗∗P < 0.001 versus vehicle control. n = 14 to 15 eyes (A and B); n = 8 eyes (C and D).
