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. 2015 Sep;185(9):2354–2363. doi: 10.1016/j.ajpath.2015.05.018

Figure 1.

Figure 1

Cutaneous squamous cell carcinoma (cSCC) caspase recruitment domain (CARD)11 mutations (n = 88) distribute evenly compared with diffuse large B-cell lymphoma (DLBCL) (n = 85). CARD11 mutations (colored vertical lines) are distributed evenly throughout all protein domains in cSCC compared with clustering within the coiled-coil and CARD domains in DLBCL. Mutations are indicated by vertical bars and were compiled from this study (66 cSCC) and the catalog of somatic mutations in cancer (22 cSCC and 85 DLBCL) (http://cancer.sanger.ac.uk/cosmic; last accessed April 15, 2015). Green lines represent missense; red lines represent nonsense; and yellow lines represent an insertion/deletion. Vertical bars above the CARD11 colored boxes indicate two or more mutations present at the same amino acid position. Orange bars above the cSCC CARD11 cartoon indicate two regions of low sequence coverage in cSCC (2 to 10 reads).