Table 1.
| a | ||||
|---|---|---|---|---|
| Tight Junctions |
Transcytosis | (25–34) | ||
| Yes | Yes | Yes** | (25–27) | |
| Yes | Yes | Yes** | (28–30), (70) | |
| Yes | Yes | Yes** | (28–35) | |
| Yes | Yes | Yes** | (25–27) (36) | |
| Yes | Yes | ND | (37) | |
| No | No | Yes | (38–44) | |
| No* | Most likely*** | ND | (45) | |
| b | ||||
|---|---|---|---|---|
| Tight Junctions | Transcytosis | |||
| Neural Progenitors; Bergmann Glia |
Yes | Yes | Yes** | (25–27) (29) (32) |
| Astrocytes | ND | Yes | ND | (47) |
| Gut Microbiota | No | Yes | ND | (49) |
*
No vascular defects were observed during embroynic analysis of LSR knockout mice
**
Loss-of-function of Wnt signaling results in elevated expression of PLVAP, a marker for fenestarted endothelial cells and transcytosis
***
Although ultrastructural analysis by EM revealed no defects in tight junction complexes, loss of LSR affects tight junctions
ND: Not Determined