Table 2. Characteristics of the study population categorized by the quartile of Gensini score.
| Characteristics | Gensini score |
Statistical parameter | Pvalue | |||
|---|---|---|---|---|---|---|
| 0(n = 40) | 0.1–9.5(n = 22) | 9.6–37.5(n = 31) | 37.5-(n = 31) | |||
| Age (years) | 55.70 ± 8.41 | 56.86 ± 9.50 | 61.68 ± 9.14 | 63.16 ± 8.70 | 5.460 | 0.001 |
| Gender (F/M) | 13/27 | 11/11 | 5/26 | 4/27 | 11.599 | 0.009 |
| TCH | 4.72 ± 0.97 | 4.52 ± 1.07 | 4.79 ± 1.10 | 4.72 ± 0.97 | 0.313 | 0.816 |
| HDL-C | 1.48 ± 0.35 | 1.51 ± 0.33 | 1.33 ± 0.28 | 1.37 ± 0.39 | 1.846 | 0.143 |
| LDL-C | 2.82 ± 0.83 | 2.61 ± 0.86 | 3.01 ± 1.00 | 2.89 ± 0.85 | 0.936 | 0.426 |
| FBG | 5.07(4.64–5.73) | 5.04(4.80–5.49) | 5.08(4.78–6.29) | 5.89(4.95–6.99) | 7.610 | 0.055 |
| CR | 69.73 ± 12.62 | 63.11 ± 7.85 | 74.73 ± 19.35 | 76.71 ± 10.58 | 5.048 | 0.003 |
| CHD (case/control) | 0/40 | 5/17 | 30/1 | 31/0 | 104.600 | 0.000 |
| miR-433 | 0.57(0.32 ~ 1.09) | 0.77(0.47 ~ 1.38) | 0.57(0.31 ~ 1.14) | 0.58(0.28 ~ 1.04) | 2.959 | 0.398 |
| miR-1 | 0.85(0.36 ~ 2.93) | 1.25(0.73 ~ 1.89) | 1.80(0.52 ~ 3.85) | 1.34(0.47 ~ 3.02) | 3.012 | 0.390 |
| miR-122 | 0.28(0.09 ~ 0.56) | 0.62(0.15 ~ 1.67) | 0.46(0.09 ~ 1.41) | 0.33(0.10 ~ 1.32) | 3.012 | 0.390 |
| miR-133a | 0.33(0.19 ~ 0.77) | 0.58(0.31 ~ 0.92) | 0.38(0.23 ~ 0.89) | 0.32(0.16 ~ 0.97) | 3.797 | 0.284 |
| miR-145 | 0.08(0.04 ~ 0.18) | 0.07(0.03 ~ 0.18) | 0.11(0.04 ~ 0.22) | 0.09(0.05 ~ 0.16) | 1.308 | 0.727 |
| miR-214 | 0.15(0.02 ~ 0.67) | 0.11(0.02 ~ 0.34) | 0.17(0.04 ~ 0.72) | 0.20(0.03 ~ 1.08) | 1.436 | 0.697 |
| miR-21 | 0.59(0.42 ~ 1.00) | 0.82(0.42 ~ 1.55) | 0.62(0.44 ~ 0.96) | 0.60(0.32 ~ 1.07) | 2.457 | 0.483 |
| miR-25 | 0.02(0.01 ~ 0.07) | 0.03(0.01 ~ 0.11) | 0.01(0.01 ~ 0.07) | 0.02(0.01 ~ 0.09) | 0.950 | 0.813 |
| miR-20a | 0.35(0.14 ~ 0.54) | 0.33(0.19 ~ 0.64) | 0.34(0.14 ~ 0.58) | 0.38(0.18 ~ 0.44) | 0.595 | 0.898 |
| miR-106a | 2.69(1.65 ~ 4.31) | 2.58(1.92 ~ 4.36) | 2.60(1.85 ~ 4.59) | 1.92(1.48 ~ 3.81) | 1.628 | 0.653 |
| miR-92a | 0.65 ± 0.95 | 1.29 ± 1.82 | 1.91 ± 6.21 | 0.26 ± 0.42 | 1.544 | 0.207 |
| miR-130a | 59.52(35.26 ~ 88.03) | 96.18(38.95 ~ 30.52) | 76.90(28.34 ~ 235.57) | 46.53(29.24 ~ 97.34) | 4.440 | 0.218 |
| miR-155 | 159.51(106.22 ~ 337.12) | 246.85(154.05 ~ 331.43) | 204.36(127.56 ~ 384.01) | 158.68(62.25 ~ 314.08) | 3.045 | 0.385 |
| miR-208b | 1.05(0.56 ~ 3.90) | 0.75(0.59 ~ 1.61) | 1.15(0.67 ~ 4.91) | 1.30(0.65 ~ 3.38) | 1.859 | 0.602 |
| miR-499 | 3.10(2.09 ~ 7.26) | 2.87(1.89 ~ 5.04) | 4.38(2.26 ~ 10.06) | 3.75(1.40 ~ 9.29) | 2.260 | 0.520 |
| miR-485-3p | 1.56(0.70 ~ 3.38) | 1.42(0.84 ~ 2.03) | 1.70(0.81 ~ 15.14) | 1.87(1.04 ~ 6.59) | 1.210 | 0.751 |
| miR-133b | 0.16(0.10 ~ 0.25) | 0.18(0.10 ~ 0.22) | 0.14(0.09 ~ 0.23) | 0.14(0.06 ~ 0.24) | 1.251 | 0.741 |
| miR-221 | 0.62(0.21 ~ 0.91) | 0.43(0.21 ~ 1.12) | 0.36(0.21 ~ 0.93) | 0.43(0.18 ~ 0.80) | 0.648 | 0.885 |
| miR-208a | 1.67(1.12 ~ 3.85) | 2.16(1.21 ~ 4.64) | 2.25(1.31 ~ 4.39) | 2.89(1.69 ~ 4.29) | 3.318 | 0.345 |
| miR-125b | 0.17 ± 0.10 | 0.19 ± 0.10 | 0.16 ± 0.09 | 0.12 ± 0.09 | 2.912 | 0.037 |
Data are summarized by either mean ± standard deviation or 50th (25th/75th) percentiles for continuous variables and N1/N2 for binary variables. CHD, coronary heart disease; TCH, total cholesterol; HDL-C, fasting high-density lipoprotein cholesterol; LDL-C, fasting low-density lipoprotein cholesterol; TG, triglyceride; FBG, fasting blood glucose; CR, creatinine. The value of each miRNAs means the relative mount calculated by 2−Δct method.