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. 2015 Oct 7;15:116. doi: 10.1186/s12872-015-0103-4

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© Tan et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Effect of PEP-1-SOD1 on ANG II-induced ROS in MCF. a-b: O₂ ⁻ levels were detected by fluorescent microscopy (a) and quantified by Flow Cytometry (b), respectively. Red color was indicated as the changes of O₂ ⁻ levels in cells detected with oxidation-sensitive fluorescent probe dihydroethidium (DHE), Blue color was indicated as cell nucleus by DAPI staining. c: PEP-1-SOD1, but not SOD1, blocked Ang II-induced increase of MDA content. d: PEP-1-SOD1, but not SOD1, restored Ang II-blocked SOD activity. *P < 0.01 vs. Vehicle-treated cells (−), ^# P < 0.01 vs. Ang II-treated cells, &P < 0.01 vs. SOD1-treated cells (n = 5). e-f: gp91^phox expression was analyzed by western blot (e) and normalized to α-Tubulin (f). *P < 0.01 vs. vehicle-treated cells (−) (n = 5)