Fig. 2.

Unsupervised hierarchical clustering of comprehensive microRNA sequencing reads using the Pearson correlation method results in independent clustering of Dupuytren’s and control palmar fascia. Only a single adjacent fascia specimen clustered with the Dupuytren’s fascia indicating that visual inspection alone may not be reliable in distinguishing between diseased and non-diseased fascia. These data show that microRNA expression patterns may be able to differentiate between diseased and non-diseased fascia and may play key roles in driving pathogenic fibrosis