Table 2.
Collagens targeted by microRNAs enriched in control palmar fascia - ComiR target prediction shows that the majority of collagens are preferentially inhibited by microRNAs enriched in control fascia compared with Dupuytren’s fascia. In our analysis of collagen expression using RT-qPCR, COL8A1 and COL15A1 were the only collagens that did not show a statistically significant increase in Dupuytren’s fascia. Notably these collagens also exhibited the lowest degree of microRNA targeting
| GENE ID | ComiR score difference (Control Fascia –Dupuytren’s Fascia) | p-value |
|---|---|---|
| COL5A3 | 0.0896 | 0.0007 |
| COL1A2 | 0.0804 | <0.001 |
| COL4A2 | 0.0630 | <0.001 |
| COL11A1 | 0.0602 | <0.001 |
| COL3A1 | 0.0543 | <0.001 |
| COL5A1 | 0.0472 | 0.0015 |
| COL18A1 | 0.0469 | 0.0033 |
| COL1A1 | 0.0431 | <0.001 |
| COL13A1 | 0.0407 | 0.0488 |
| COL21A1 | 0.0387 | <0.001 |
| COL15A1 | 0.0386 | 0.0005 |
| COL5A2 | 0.0381 | 0.0006 |
| COL7A1 | 0.0344 | <0.001 |
| COL12A1 | 0.0330 | 0.0749 |
| COL16A1 | 0.0192 | 0.0028 |
| COL4A4 | −0.0031 | 0.1286 |
| COL27A1 | −0.0103 | 0.3310 |
| COL8A1 | −0.0136 | 0.1502 |
| COL2A1 | −0.0186 | 0.0141 |
| COL4A1 | −0.0187 | 0.3535 |
| COL6A1 | −0.0238 | 0.0715 |
| COL6A3 | −0.0245 | 0.0523 |
| COL8A2 | −0.0463 | <0.001 |
| COL6A2 | −0.1577 | <0.001 |