Table 5.
Effect of AETS 100, 200 and 300 mg/kg in tail immersion test
| Samples/standard | Dose mg/kg | Tail withdrawing time in sec | ||||
|---|---|---|---|---|---|---|
| 0 min | 30 min | 60 min | 90 min | 120 min | ||
| Normal saline | 10 ml/kg | 3.35 ± 0.11 | 3.48 ± 0.16 | 3.22 ± 0.032 | 3.39 ± 0.20 | 3.34 ± 0.19 |
| AETS | 100 mg/kg | 3.35 ± 0.04n.s | 3.61 ± 1.03 n.s | 4.02 ± 1.03* | 3.96 ± 0.4* | 3.76 ± 1.04 * |
| 200 mg/kg | 3.36 ± 1.34 n.s | 4.19 ± 1.07* | 4.55 ± 0.07** | 4.48 ± 0.1** | 4.20 ± 2.10** | |
| 300 mg/kg | 3.37 ± 0.4 n.s | 4.80 ± 0.21* | 5.36 ± 0.11** | 5.30 ± 0.12** | 5.03 ± 0.10** | |
| TramadolR | 30 mg/kg | 3.5 ± 0.20 n.s | 4.99 ± 1.33** | 5.69 ± 0.02** | 5.49 ± 0.06** | 5.39 ± 0.05** |
| Antinociceptive effect of AETS and TramadolR antagonized by Naloxone | ||||||
| AETS | 300 mg/kg | 3.37 ± 1.05 n.s | 4.10 ± 2.10 n.s | 4.13 ± 1.07 n.s | 4.20 ± 1.05 n.s | 4.26 ± 1.70 n.s |
| TramadolR | 30 mg/kg | 3.38 ± 1.04 n.s | 3.75 ± 2.41 n.s | 3.72 ± 1.50 n.s | 3.75 ± 1.02 n.s | 3.70 ± 1.04 n.s |
Values expressed as mean ± SEM, The data was analyzed by ANOVA followed by Dunnett’s test, n.s shows statistically non significant values, **p <0.01 and *p <0.05 vs. control group (n = 6)