Fig. 5.

Relationship between subtelomeric methylation status and telomere length in glioma. a Relative telomere length (T/S), expressed as the relative ratio of the copy number of telomeric repeats to a single copy gene 36B4, in both control and glioma patients. Correlation between telomere length (TL) and subtelomeric methylation ratio (as obtained from MSP) at five chromosomal ends was evaluated in both the control and glioma patients (b–f). Methylations in glioma and control patients are presented with pink dots and blue dots, respectively, while the resulting linear lines correspond to each group were presented by a black and gray lines, respectively. We did not observe any significant correlation between the methylation ratios to the global change in TL