Table 1.

Percent Bias and Standard Error of Estimates of Log Relative Risk for the Association Between 3 Gene Types and the Risk of Colorectal Cancer Among Population-Based Families in the Colon Cancer Family Registry, 1997–2007

Pr(Screen | FH Polyps)	Pr(Screen | FH CRC)	Pr(CRC Prevented | Polyp Detected)	G1 Bias				G2 Bias				G3 Bias
			CRC vs. No CRC		CRC vs. Neither CRC Nor Detected Polypc	CRC or Detected Polyp vs. Neitherd	CRC vs. No CRC		CRC vs. Neither CRC Nor Detected Polypc	CRC or Detected Polyp vs. Neitherd	CRC vs. No CRC		CRC vs. Neither CRC Nor Detected Polypc	CRC or Detected Polyp vs. Neitherd
			Unadjusteda	Adjusted for Polypsb			Unadjusteda	Adjusted for Polypsb			Unadjusteda	Adjusted for Polypsb
0.00	0.00	0.00	−3	−61e	−41e	55e	0	8	17	−13	−4	2	−16	−30e
0.25	0.00	0.00	−2	−65e	−43e	61e	−1	7	16	−14	7	15	−8	−25
0.00	0.75	0.00	−4	−93e	−64e	73e	2	18	36e	−18	2	18	−17	−41e
0.00	0.00	0.50	−10	−51e	−23	98e	−3	−1	7	−17	6	7	−8	−20
0.25	0.75	0.50	2	−91e	−47e	147e	−2	4	24	−21	−2	3	−23	−41e

Abbreviations: CRC, colorectal cancer; FH, family history; G_1–G₃, simulated genes related to CRC development through risk of polyps, risk of CRC but not polyps, and progression from polyps to CRC, respectively; ln RR, natural log of relative risk; Pr, probability.

^a Strategy 1: standard error of ln RR = 0.086.

^b Strategy 2: standard error of ln RR = 0.091.

^c Strategy 3: standard error of ln RR = 0.115.

^d Strategy 4: standard error of ln RR = 0.086.

^e Absolute bias is greater than 25% of the true value.